With noise reduction software it is a case of picking your poison. Well I hope this poison at least offers a pleasant taste!
I’ve played with using motion compensation to align image stacks for noise reduction before, but I thought I would have another go.
Here is a method for reducing noise in a images by using multiple shots taken in sequence and blending them together. The key to this method is each shot is motion compensated to match a reference shot, so modest amount of subject or camera movement have little affect the outcome. That is, this method does not require a tripod, or a perfectly still subject.